Author(s): Yamamuro A, Ago Y, Maeda S, Sakai Y, Baba A,
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Abstract The present study examines the effect of the cognition enhancer (1R)-1-benzo[b]thiophen-5-yl-2-[2-(diethylamino)ethoxy]ethan-1-ol hydrochloride (T-588) on neuronal injury induced by serum deprivation or amyloid-beta protein (A beta). T-588 protected partially against neuronal injury induced by serum deprivation or A beta in cultured cortical neurons. T-588 did not affect the phosphorylation of extracellular signal-regulated kinase (ERK) in cortical neurons and SH-SY5Y cells. These results suggest that T-588 has a protective effect in neuronal injury models and the effect is not mediated by an ERK signal pathway.
This article was published in J Pharmacol Sci
and referenced in Journal of Clinical & Experimental Ophthalmology