alexa Protective role of lung surfactant protein D in a murine model of invasive pulmonary aspergillosis.
Medicine

Medicine

Journal of Medical Diagnostic Methods

Author(s): Madan T, Kishore U, Singh M, Strong P, Hussain EM, , Madan T, Kishore U, Singh M, Strong P, Hussain EM,

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Abstract The protective effects of intranasal administration of amphotericin B (AmB), human SP-A, SP-D and a 60-kDa fragment of SP-D (rSP-D) were examined in a murine model of invasive pulmonary aspergillosis (IPA). The untreated group of IPA mice showed no survival at 7 days postinfection. Treatment with AmB, SP-D, and rSP-D increased the survival rate to 80, 60, and 80\%, respectively, suggesting that SP-D (and rSP-D) can protect immunosuppressed mice from an otherwise fatal challenge with Aspergillus fumigatus conidia.
This article was published in Infect Immun and referenced in Journal of Medical Diagnostic Methods

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