alexa Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro.
Oncology

Oncology

Journal of Nuclear Medicine & Radiation Therapy

Author(s): Siddique YH, Ara G, Beg T, Afzal M

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Abstract Antioxidants and plant products are reported to reduce the genotoxic damage of steroids. In our present study we have tested different dosages of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in the presence of S9 mix. Treatments with nordihydroguaiaretic acid (NDGA) results in the reduction of the genotoxic damage. A significant decrease was observed at all the tested doses of NDGA in sister chromatic exchanges of number of abnormal cells. The results suggest a protective role of NDGA against the genotoxic damage.
This article was published in J Environ Biol and referenced in Journal of Nuclear Medicine & Radiation Therapy

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