Author(s): Goldstein JL, DeBoseBoyd RA, Brown MS
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Abstract Cholesterol is an essential component of animal cell membranes, and its concentration is tightly controlled by a feedback system that operates at transcriptional and posttranscriptional levels. Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake.
This article was published in Cell
and referenced in Lupus: Open Access