Author(s): Spangrude GJ, Heimfeld S, Weissman IL
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Abstract Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of phenotypic markers. These cells can proliferate and differentiate with approximately unit efficiency into myelomonocytic cells, B cells, or T cells. Thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors.
This article was published in Science
and referenced in Journal of Stem Cell Research & Therapy