alexa Putative circulating markers of the early and advanced stages of breast cancer identified by high-resolution label-free proteomics.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Panis C, Pizzatti L, Herrera AC, Cecchini R, Abdelhay E

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Abstract This study evaluated the plasmatic proteomic profile of breast cancer patients in the early (ED) and advanced (AD) stages, employing high-throughput proteomics. We identified 92 differentially expressed proteins in ED and 73 proteins in AD patients. Gelsolin, lumican, clusterin, SALL4 and PMS2, as well hTERT, TNF-α and GRHL3 were chosen for further investigation. ED presented augmented expression of GRHL3 and reduced circulating TNF-α with high expression of GRHL3 in tumors. AD displayed high TNF-α and a significant expression of PMS2 in tumors. These findings suggest processes enrolling stem cell division in ED, with TNF-α signaling and DNA mismatch repair in the advanced stage. Copyright © 2012. Published by Elsevier Ireland Ltd. This article was published in Cancer Lett and referenced in Journal of Cytology & Histology

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