Author(s): Serrano M, Blasco MA
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Abstract Cultivation of primary cells over many generations eventually results in a reproducible loss of proliferative potential that has been termed 'replicative senescence'. Recent work has revealed the heterogeneity of senescence. Importantly, the analysis of the various aspects and types of senescence has turned out to be very informative about numerous in vivo processes, and particularly about carcinogenesis.
This article was published in Curr Opin Cell Biol
and referenced in Journal of Carcinogenesis & Mutagenesis