alexa Pyrrole-coupled salicylimine-based fluorescence "turn on" probe for highly selective recognition of Zn²⁺ ions in mixed aqueous media: Application in living cell imaging.


Biochemistry & Analytical Biochemistry

Author(s): Bhosale J, Fegade U, Bondhopadhyay B, Kaur S, Singh N,

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Abstract Cation sensing behaviour of a pyrrole-based derivative (2-hydroxyl 3 methyl 6 isopropyl benzaldehyde}-3,4-dimethyl-1H-pyrrole-2-carbohydrazide (receptor 3) has been explored and is found to be selective towards Zn(2+) over a variety of tested cations. The receptor 3 has shown high selectivity and sensitivity towards Zn(2+) over the other alkali, alkaline earth and transition metal ions. In the presence of Zn(2+), absorption band of receptor 3 has shown the red shift. The sensing behaviour has been suggested to continue via enhancement process which has further been supported by UV-vis absorption and theoretical density functional theory (DFT) calculations indicating the formation of a 1:1 complex between the pyrrole based receptor 3 and Zn(2+). The present work is presenting a highly selective dual channel colorimetric sensor for zinc with great sensitivity. The developed sensor was successfully applied to image intracellular Zn(2+) in living cells. Copyright © 2015 John Wiley & Sons, Ltd. This article was published in J Mol Recognit and referenced in Biochemistry & Analytical Biochemistry

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