alexa Quantification of pancreatic lipomatosis and liver steatosis by MRI: comparison of in opposed-phase and spectral-spatial excitation techniques.
Diabetes & Endocrinology

Diabetes & Endocrinology

Pancreatic Disorders & Therapy

Author(s): Schwenzer NF, Machann J, Martirosian P, Stefan N, Schraml C,

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Abstract OBJECTIVES: The goal of the present study was the assessment of pancreatic and hepatic fat content applying 2 established magnetic resonance (MR) imaging techniques: in-phase/opposed-phase gradient-echo MR imaging and fat-selective spectral-spatial gradient-echo imaging. Results of both approaches were compared, and influences of T1- and T2*-related corrections were assessed. The possibility of a correlation between pancreatic lipomatosis and liver steatosis was investigated. MATERIALS AND METHODS: Seventeen volunteers at risk for type 2 diabetes (6 male, 11 female; age, 26-70 years; body mass index, 19.4-41.3 kg/m2; mean, 31.7 kg/m2) were examined. Liver and pancreas fat content were quantified with 2 different gradient-echo techniques: one uses a spectral-spatial excitation technique with 6 binomial radio frequency pulses, which combines chemical shift selectivity with simultaneous slice-selective excitation. The other technique based on double-echo chemical shift gradient-echo MR provides in- and opposed-phase images simultaneously. Influences of T1 and individual T2* effects on results using in-phase/opposed-phase imaging were estimated and corrected for, based on additional T2* measurements. RESULTS: The fat content calculated from images recorded with the fat-selective spectral-spatial gradient-echo sequence correlated well with the fat fraction determined with in-phase/opposed-phase imaging and following correction for T1/T2* effects: pancreas r = 0.93 (P < 0.0001) and liver r = 0.96 (P < 0.0001). In-phase/opposed-phase imaging revealed a pancreatic fat content between 1.6\% and 22.2\% (mean, 8.8\% +/- 5.7\%) and a hepatic fat fraction between 0.6\% and 33.3\% (mean, 7.9\% +/- 9.1\%). The fat-selective spectral-spatial gradient-echo sequence revealed a pancreatic lipid content between 3.4\% and 16.1\% (mean, 9.8\% +/- 4.0\%) and a hepatic fat content between 0\% and 28.5\% (mean, 8.8\% +/- 8.3\%). With neither technique was a substantial correlation between pancreatic and hepatic fat content found. CONCLUSION: The presented results suggest that both methods are reliable tools for pancreatic and hepatic fat quantification. However, for reliable assessment of quantitative fat by the in-phase/opposed-phase technique, an additional measurement of T2* seems crucial. This article was published in Invest Radiol and referenced in Pancreatic Disorders & Therapy

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