alexa Quantification of voriconazole in plasma by liquid chromatography-tandem mass spectrometry.
Biomedical Sciences

Biomedical Sciences

Journal of Bioanalysis & Biomedicine

Author(s): Vogeser M, Schiel X, Sphrer U

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Abstract A convenient liquid chromatography-tandem mass spectrometry method for the quantification of the triazole antifungal agent voriconazole in plasma samples is described. Fenbuconazole is used as an internal standard. After protein precipitation, automated solid-phase extraction is applied. Electrospray ionization in the positive mode is used and the following mass transitions are recorded: voriconazole, 350-->127; and fenbuconazol, 337-->125. The analytical run time is 4 min. The response was linear from 78 to 5000 microg/L. The total coefficient of variation (n=16) was 12.6\% for a low-concentration pool (143 microg/L), 4.7\% for a medium-concentration pool (419 microg/L), and 5.0\% for a high-concentration pool (4304 microg/L). The method is proposed for future investigations that should be performed to test the hypothesis that therapeutic drug monitoring of voriconazole is clinically useful. This article was published in Clin Chem Lab Med and referenced in Journal of Bioanalysis & Biomedicine

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