alexa Quantitative analysis of 1-(2-pyrimidinyl)piperazine in plasma by capillary gas chromatography-mass spectrometry.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Kerns EH, Bullen WW, Gammans RE

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Abstract A sensitive method for detecting and quantifying 1-(2-pyrimidinyl)piperazine, an important metabolite of buspirone, in human plasma was developed and validated. The range of the method is 0.2-15 ng/ml. The analyte was removed from buffered, sodium chloride-saturated plasma with benzene, extracted into aqueous acid, washed with diethyl ether and reextracted into benzene. The processed extract was derivatized with pentafluorobenzoyl chloride. Instrumental analysis involved on-column injection into a fused-silica capillary gas chromatography column and detection by selected-ion monitoring mass spectrometry.
This article was published in J Chromatogr and referenced in Pharmaceutica Analytica Acta

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