alexa Quantitative signal detection using spontaneous ADR reporting.
Microbiology

Microbiology

Journal of Microbial & Biochemical Technology

Author(s): Bate A, Evans SJ

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Abstract Quantitative methods are increasingly used to analyse spontaneous reports. We describe the core concepts behind the most common methods, the proportional reporting ratio (PRR), reporting odds ratio (ROR), information component (IC) and empirical Bayes geometric mean (EBGM). We discuss the role of Bayesian shrinkage in screening spontaneous reports, the importance of changes over time in screening the properties of the measures. Additionally we discuss three major areas of controversy and ongoing research: stratification, method evaluation and implementation. Finally we give some suggestions as to where emerging research is likely to lead. This article was published in Pharmacoepidemiol Drug Saf and referenced in Journal of Microbial & Biochemical Technology

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