alexa Quercetin protects rat liver against lead-induced oxidative stress and apoptosis.


Journal of Environmental & Analytical Toxicology

Author(s): Liu CM, Zheng YL, Lu J, Zhang ZF, Fan SH, , Liu CM, Zheng YL, Lu J, Zhang ZF, Fan SH,

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Abstract Quercetin, a flavonoid, effectively improved the lead-induced histology changes including structure damage and leukocyte infiltration in rat liver. The present study was designed to explore the protective mechanism of quercetin against lead-induced hepatic injury. We found that quercetin markedly decreased the MDA and H(2)O(2) levels and lowered the GSH/GSSG ratio in the liver of lead-treated rat. Moreover, quercetin markedly restored Cu/Zn-SOD, Mn-SOD, CAT and GPx activities and upregulated mRNA expression levels of these proteins in the liver of lead-treated rat. Western blot analysis showed that quercetin significantly inhibited apoptosis by modulating the ratio of Bax to Bcl-2 expression and suppressing the expression of phosphorylated JNK1/2 and cleaved caspase-3 in the liver of lead-treated rat. In conclusion, these data suggest that quercetin protects the rat liver from lead-induced injury by attenuating lipid peroxidation, renewing the activities of antioxidant enzymes and inhibiting apoptosis. Crown Copyright © 2010. Published by Elsevier B.V. All rights reserved. This article was published in Environ Toxicol Pharmacol and referenced in Journal of Environmental & Analytical Toxicology

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