alexa Racial and ethnic differences in advanced-stage prostate cancer: the Prostate Cancer Outcomes Study.
Oncology

Oncology

Journal of Prostate Cancer

Author(s): Hoffman RM, Gilliland FD, Eley JW, Harlan LC, Stephenson RA, , Hoffman RM, Gilliland FD, Eley JW, Harlan LC, Stephenson RA,

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Abstract BACKGROUND: African-Americans have twice the risk of non-Hispanic whites for presenting with advanced-stage prostate cancer. To investigate the reasons for this difference, we evaluated the association between race/ethnicity and advanced-stage prostate cancer, adjusting for demographic, socioeconomic, clinical, and pathologic factors. METHODS: A population-based cohort of 3173 men diagnosed with prostate cancer between October 1, 1994, and October 31, 1995, was analyzed. Medical record abstracts and self-administered survey questionnaires were used to obtain information regarding race/ethnicity, age, marital status, insurance status, educational level, household income, employment status, comorbidity, urinary function, prostate-specific antigen level, tumor grade, and clinical stage. The odds ratio (OR) for advanced-stage prostate cancer was estimated with weighted logistic regression analysis. All P: values were two-sided. RESULTS: Clinically advanced-stage prostate cancers were detected more frequently in African-Americans (12.3\%) and Hispanics (10.5\%) than in non-Hispanic whites (6.3\%). Socioeconomic, clinical, and pathologic factors each accounted for about 15\% of the increased relative risk. After adjusting for all covariates, the risk remained statistically significantly increased for African-Americans (OR = 2.26; 95\% confidence interval [CI] = 1.43 to 3.58) but not for Hispanics (OR = 1.23; 95\% CI = 0.73 to 2.08). CONCLUSION: Traditional socioeconomic, clinical, and pathologic factors accounted for the increased relative risk for presenting with advanced-stage prostate cancer in Hispanic but not in African-American men.
This article was published in J Natl Cancer Inst and referenced in Journal of Prostate Cancer

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