Author(s): BarcellosHoff MH, Park C, Wright EG
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Abstract Radiation rapidly and persistently alters the soluble and insoluble components of the tissue microenvironment. This affects the cell phenotype, tissue composition and the physical interactions and signalling between cells. These alterations in the microenvironment can contribute to carcinogenesis and alter the tissue response to anticancer therapy. Examples of these responses and their implications are discussed with a view to therapeutic intervention.
This article was published in Nat Rev Cancer
and referenced in Advancements in Genetic Engineering