Author(s): Palumbo B, Palumbo R, Sinzinger H
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Abstract BACKGROUND: Radiotherapy can cause vascular injury. No data on radioiodine therapy and vascular damage are available. MATERIAL AND METHODS: We examined the number of circulating endothelial cells (CEC) and circulating endothelial progenitor cells (CEPC) before therapy 1, 2, 3 and 5 days as well as 1, 2, 3, 4, 6, 8, 10, and 12 weeks after therapy with (131)I at doses ranging from 5-200 mCi. The individual number of CEC and CEPC is associated with the presence of risk factors. RESULTS: Irrespective of prevalues, CEC exhibited a significant dose-dependent temporary increase reaching the maximum in weeks 1 and 2. In contrast, CEPC show a decrease at the same time. CONCLUSIONS: These results indicate that (131)I-therapy induces a dose-dependent radiation injury at the vascular wall level enhancing endothelial desquamation and reducing reendothelialization and thereby a proatherogenic stage. The clinical consequence of these findings still needs to be assessed.
This article was published in Nucl Med Rev Cent East Eur
and referenced in Journal of Nuclear Medicine & Radiation Therapy