alexa Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS).
Cardiology

Cardiology

Journal of Hypertension: Open Access

Author(s): Flather MD, Shibata MC, Coats AJ, Van Veldhuisen DJ, Parkhomenko A,

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Abstract AIMS: Large randomized trials have shown that beta-blockers reduce mortality and hospital admissions in patients with heart failure. The effects of beta-blockers in elderly patients with a broad range of left ventricular ejection fraction are uncertain. The SENIORS study was performed to assess effects of the beta-blocker, nebivolol, in patients >/=70 years, regardless of ejection fraction. METHODS AND RESULTS: We randomly assigned 2128 patients aged >/=70 years with a history of heart failure (hospital admission for heart failure within the previous year or known ejection fraction 35\%), and 68\% had a prior history of coronary heart disease. The mean maintenance dose of nebivolol was 7.7 mg and of placebo 8.5 mg. The primary outcome occurred in 332 patients (31.1\%) on nebivolol compared with 375 (35.3\%) on placebo [hazard ratio (HR) 0.86, 95\% CI 0.74-0.99; P=0.039]. There was no significant influence of age, gender, or ejection fraction on the effect of nebivolol on the primary outcome. Death (all causes) occurred in 169 (15.8\%) on nebivolol and 192 (18.1\%) on placebo (HR 0.88, 95\% CI 0.71-1.08; P=0.21). CONCLUSION: Nebivolol, a beta-blocker with vasodilating properties, is an effective and well-tolerated treatment for heart failure in the elderly. This article was published in Eur Heart J and referenced in Journal of Hypertension: Open Access

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