alexa Rapid culture-based methods for drug-resistance detection in Mycobacterium tuberculosis.
Microbiology

Microbiology

Journal of Antivirals & Antiretrovirals

Author(s): Palomino JC, Martin A, Von Groll A, Portaels F

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Abstract Tuberculosis still represents a major public health problem, especially in low-resource countries where the burden of the disease is more important. Multidrug-resistant and extensively drug drug-resistant tuberculosis constitute serious problems for the efficient control of the disease stressing the need to investigate resistance to first- and second-line drugs. Conventional methods for detecting drug-resistance in Mycobacterium tuberculosis are slow and cumbersome. The most commonly used proportion method on Löwenstein-Jensen medium or Middlebrook agar requires a minimum of 3-4 weeks to produce results. Several new approaches have been proposed in the last years for the rapid and timely detection of drug-resistance in tuberculosis. This review will address phenotypic culture-based methods for rapid drug susceptibility testing in M. tuberculosis. This article was published in J Microbiol Methods and referenced in Journal of Antivirals & Antiretrovirals

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