alexa Rapid progression to disease in African sex workers with human immunodeficiency virus type 1 infection.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Anzala OA, Nagelkerke NJ, Bwayo JJ, Holton D, Moses S, , Anzala OA, Nagelkerke NJ, Bwayo JJ, Holton D, Moses S,

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Abstract From a cohort of female sex workers in Nairobi, Kenya, 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-1-related disease. The effect of several covariables on disease progression was studied using a Weibull proportional hazards model. The Weibull survival model was fitted to the observed incubation times. Estimates of the median duration to CDC stage IV-A and IV-C disease were 3.5 and 4.4 years, respectively. Condom use before seroconversion was associated with a reduced risk of CDC stage IV-A disease (relative risk = .64, P < .05). The incubation time of HIV-1-related disease is extremely short in this population.
This article was published in J Infect Dis and referenced in Journal of AIDS & Clinical Research

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