alexa RAR and RXR modulation in cancer and metabolic disease.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Altucci L, Leibowitz MD, Ogilvie KM, de Lera AR, Gronemeyer H

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Abstract Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell growth and survival. The success of RAR modulation in the treatment of acute promyelocytic leukaemia (APL) has stimulated considerable interest in the development of RAR and RXR modulators. This has been aided by recent advances in the understanding of the biological role of RARs and RXRs and in the design of selective receptor modulators that might overcome the limitations of current drugs. Here, we discuss the challenges and opportunities for therapeutic strategies based on RXR and RAR modulators, with a focus on cancer and metabolic diseases such as diabetes and obesity. This article was published in Nat Rev Drug Discov and referenced in Journal of Cytology & Histology

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