Author(s): Speck SH, Chatila T, Flemington E
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Abstract The switch from latent infection to virus replication in Epstein-Barr virus (EBV)-infected B cells is initiated by expression of the viral BZLF1 gene. Recent studies have identified the key cellular transcription factors involved in regulating this switch in viral programs and the signal transduction pathways to which they respond. Understanding this switch may facilitate development of strategies to interfere with EBV infection.
This article was published in Trends Microbiol
and referenced in Medicinal chemistry