alexa Reactive Oxygen Species Modulation of Na K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling.
Cardiology

Cardiology

Journal of Hypertension: Open Access

Author(s): Liu J, Kennedy DJ, Yan Y, Shapiro JI

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Abstract The Na/K-ATPase is the primary force regulating renal sodium handling and plays a key role in both ion homeostasis and blood pressure regulation. Recently, cardiotonic steroids (CTS)-mediated Na/K-ATPase signaling has been shown to regulate fibrosis, renal proximal tubule (RPT) sodium reabsorption, and experimental Dahl salt-sensitive hypertension in response to a high-salt diet. Reactive oxygen species (ROS) are an important modulator of nephron ion transport. As there is limited knowledge regarding the role of ROS-mediated fibrosis and RPT sodium reabsorption through the Na/K-ATPase, the focus of this review is to examine the possible role of ROS in the regulation of Na/K-ATPase activity, its signaling, fibrosis, and RPT sodium reabsorption.
This article was published in Int J Nephrol and referenced in Journal of Hypertension: Open Access

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