Author(s): Chiang YM, Chang SL, Oakley BR, Wang CC
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Abstract Secondary metabolites from microorganisms have a broad spectrum of applications, particularly in therapeutics. The growing number of sequenced microbial genomes has revealed a remarkably large number of natural product biosynthetic clusters for which the products are still unknown. These cryptic clusters are potentially a treasure house of medically useful compounds. The recent development of new methodologies has made it possible to begin unlock this treasure house, to discover new natural products and to determine their biosynthesis pathways. This review will highlight some of the most recent strategies to activate silent biosynthetic gene clusters and to elucidate their corresponding products and pathways. Copyright © 2010 Elsevier Ltd. All rights reserved.
This article was published in Curr Opin Chem Biol
and referenced in Biochemistry & Analytical Biochemistry