alexa Recent advances in molecular pharmacology of the histamine systems: roles of C-terminal tails of histamine receptors.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Clinical & Experimental Pharmacology

Author(s): Kuramasu A, Sukegawa J, Yanagisawa T, Yanai K

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Abstract G-protein-coupled receptors (GPCR) represent a large and diverse superfamily of integral membrane proteins to which histamine receptors belong. Increasing numbers of proteins have been identified to interact with the C-termini of GPCRs. These interactions are implicated in targeting, trafficking, and fine-tuning of signaling of GPCRs. Although the C-terminus of the histamine H2 receptor has been suggested to play in agonist-induced internalization of the receptor, roles of the C-termini of the other three histamine receptors are not known. To date, there is no protein identified to interact with the C-termini of histamine receptors.
This article was published in J Pharmacol Sci and referenced in Journal of Clinical & Experimental Pharmacology

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