alexa Recent developments in targeting protein misfolding diseases.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Glycomics & Lipidomics

Author(s): Denny RA, Gavrin LK, Saiah E

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Abstract Protein misfolding is an emerging field that crosses multiple therapeutic areas and causes many serious diseases. As the biological pathways of protein misfolding become more clearly elucidated, small molecule approaches in this arena are gaining increased attention. This manuscript will survey current small molecules from the literature that are known to modulate misfolding, stabilization or proteostasis. Specifically, the following targets and approaches will be discussed: CFTR, glucocerebrosidase, modulation of toxic oligomers, serum amyloid P (SAP) sections and HSF1 activators. Copyright © 2013 Elsevier Ltd. All rights reserved.

This article was published in Bioorg Med Chem Lett and referenced in Journal of Glycomics & Lipidomics

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