alexa Recombinant Sindbis viruses expressing a cytotoxic T-lymphocyte epitope of a malaria parasite or of influenza virus elicit protection against the corresponding pathogen in mice.


Journal of Vaccines & Vaccination

Author(s): Tsuji M, Bergmann CC, TakitaSonoda Y, Murata K, Rodrigues EG,

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Abstract Subcutaneous administration in mice of recombinant Sindbis viruses expressing a class I major histocompatibility complex-restricted 9-mer epitope of the Plasmodium yoelii circumsporozoite protein or the nucleoprotein of influenza virus induces a large epitope-specific CD8(+) T-cell response. This immunization also elicits a high degree of protection against infection with malaria or influenza A virus.
This article was published in J Virol and referenced in Journal of Vaccines & Vaccination

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