alexa Rectal cancer with paraneoplastic nephropathy: association of vascular endothelial growth factor.
Nephrology

Nephrology

Journal of Nephrology & Therapeutics

Author(s): Taniguchi K, Fujioka H, Torashima Y, Yamaguchi J, Izawa K,

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Abstract A patient with advanced rectal cancer was complicated by progressing proteinuria and hypoproteinemia. Low anterior resection was a procedure of choice. A surgical specimen obtained by intraoperative renal biopsy showed the findings of minimal change nephrotic syndrome. After surgery, nephropathy remitted promptly and completely. Her pre/postoperative serum level of vascular endothelial growth factor was 1,880/52.3 pg/ml, suggesting its elevation was associated with the nephropathy. Immunohistochemistry revealed strongly expressed tumor vascular endothelial cell growth factor. Minimal change nephrotic syndrome is a rare type of paraneoplastic nephropathy, and successful remission may require therapeutic resection of the underlying tumor, or administration of a vascular endothelial growth factor antagonist if the tumor is unresectable. Copyright 2004 S. Karger AG, Basel. This article was published in Dig Surg and referenced in Journal of Nephrology & Therapeutics

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