alexa Rectal transmission of transmitted founder HIV-1 is efficiently prevented by topical 1\% tenofovir in BLT humanized mice.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Chateau ML, Denton PW, Swanson MD, McGowan I, Garcia JV, Chateau ML, Denton PW, Swanson MD, McGowan I, Garcia JV

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Abstract Rectal microbicides are being developed to prevent new HIV infections in both men and women. We focused our in vivo preclinical efficacy study on rectally-applied tenofovir. BLT humanized mice (n = 43) were rectally inoculated with either the primary isolate HIV-1JRCSF or the MSM-derived transmitted/founder (T/F) virus HIV-1THRO within 30 minutes following treatment with topical 1\% tenofovir or vehicle. Under our experimental conditions, in the absence of drug treatment we observed 50\% and 60\% rectal transmission by HIV-1JRCSF and HIV-1THRO, respectively. Topical tenofovir reduced rectal transmission to 8\% (1/12; log rank p = 0.03) for HIV-1JRCSF and 0\% (0/6; log rank p = 0.02) for HIV-1THRO. This is the first demonstration that any human T/F HIV-1 rectally infects humanized mice and that transmission of the T/F virus can be efficiently blocked by rectally applied 1\% tenofovir. These results obtained in BLT mice, along with recent ex vivo, Phase 1 trial and non-human primate reports, provide a critically important step forward in the development of tenofovir-based rectal microbicides.
This article was published in PLoS One and referenced in Journal of AIDS & Clinical Research

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