alexa Redox cycling in iron uptake, efflux, and trafficking.


Journal of Environmental Analytical Chemistry

Author(s): Kosman DJ, Kosman DJ

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Abstract Aerobic organisms are faced with a dilemma. Environmental iron is found primarily in the relatively inert Fe(III) form, whereas the more metabolically active ferrous form is a strong pro-oxidant. This conundrum is solved by the redox cycling of iron between Fe(III) and Fe(II) at every step in the iron metabolic pathway. As a transition metal ion, iron can be "metabolized" only by this redox cycling, which is catalyzed in aerobes by the coupled activities of ferric iron reductases (ferrireductases) and ferrous iron oxidases (ferroxidases).
This article was published in J Biol Chem and referenced in Journal of Environmental Analytical Chemistry

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