alexa Reduced Accumulation of Specific MicroRNAs in Colorectal Neoplasia11 Note: Susan M. O' Connor and Nicholas G. van Holst Pellekaan contributed equally to this work.


Journal of Gastrointestinal Cancer and Stromal Tumors

Author(s): Michael Z Michael, Susan M O Connor

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Short non-coding RNAs are known to regulate cellular processes including development, heterochromatin for- mation, and genomic stability in eukaryotes. Given the impact of these processes on cellular identity, a study was undertaken to investigate possible changes in microRNA (miRNA) levels during tumorigenesis. A total of 28 different miRNA sequences was identified in a colonic adenocarcinoma and normal mucosa, including 3 novel sequences and a further 7 that had previously been cloned only from mice. Human homologues of murine miRNA sequences, miR-143 and miR-145, con- sistently display reduced steady-state levels of the mature miRNA at the adenomatous and cancer stages of colorectal neoplasia.

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This article was published in Cancer Genes and Genomics and referenced in Journal of Gastrointestinal Cancer and Stromal Tumors

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