alexa Reduced Accumulation of Specific MicroRNAs in Colorectal Neoplasia11 Note: Susan M. O' Connor and Nicholas G. van Holst Pellekaan contributed equally to this work.


Journal of Gastrointestinal Cancer and Stromal Tumors

Author(s): Michael Z Michael, Susan M O Connor

Abstract Share this page

Short non-coding RNAs are known to regulate cellular processes including development, heterochromatin for- mation, and genomic stability in eukaryotes. Given the impact of these processes on cellular identity, a study was undertaken to investigate possible changes in microRNA (miRNA) levels during tumorigenesis. A total of 28 different miRNA sequences was identified in a colonic adenocarcinoma and normal mucosa, including 3 novel sequences and a further 7 that had previously been cloned only from mice. Human homologues of murine miRNA sequences, miR-143 and miR-145, con- sistently display reduced steady-state levels of the mature miRNA at the adenomatous and cancer stages of colorectal neoplasia.

  • To read the full article Visit
  • Open Access
This article was published in Cancer Genes and Genomics and referenced in Journal of Gastrointestinal Cancer and Stromal Tumors

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 3rd International Conference on Urologic Oncology
    June 26-28, Baltimore, USA
  • 2nd International Conference on Tumor & Cancer Immunology and Immunotherapy
    July 17-19, Chicago, USA

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version