alexa Reduced pulmonary function and its associations in type 2 diabetes: the Fremantle Diabetes Study
Nursing

Nursing

Advanced Practices in Nursing

Author(s): Timothy ME Davis, Matthew Knuiman, Peter Kendall, Hien Vu, Wendy A Davis

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To determine whether diabetes is associated with reduced lung function, we studied 421 Anglo-Celt/European subjects, representing 20.5% of all patients with type 2 diabetes identified in an urban Australian catchment area of 120 097 people. In addition to collection of detailed demographic and diabetes-specific data, spirometry was performed and forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), vital capacity (VC) and peak expiratory flow (PEF) measured. When expressed as a percentage of those predicted (%pred) for age, sex and height, the means of all spirometric measures were reduced by ≥9.5%. After controlling for smoking, age and gender in a linear regression model, HbA1c was not associated with any measure of lung function (P>0.13) but diabetes duration was significantly associated with FEV1%pred and PEF%pred (P≤0.04) and had borderline associations with FVC%pred and VC%pred (P≤0.064). In separate analyses controlling for smoking alone, age, body mass index (BMI), coronary heart disease (CHD) and retinopathy were independently and inversely associated with FVC%pred, FEV1%pred and VC%pred (P<0.05). In sub-group analyses, these three spirometric measures were associated with BMI, CHD and diabetes duration in males, and age and BMI in females. Pulmonary function is reduced in type 2 diabetes. Diabetes duration seems a more important influence than glycaemic control, but obesity and vascular disease may also contribute.

This article was published in Diabetes Research and Clinical Practice and referenced in Advanced Practices in Nursing

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