alexa Reduced superoxide dismutase activity in erythrocytes of dialysis patients: a possible factor in the etiology of uremic anemia.
Clinical Research

Clinical Research

Journal of Clinical Research & Bioethics

Author(s): ShainkinKestenbaum R, Caruso C, Berlyne GM

Abstract Share this page

Superoxide dismutase (SOD) plays a major part in the destruction of oxygen-free radicals in the body. SOD activity is impaired by several trace elements including aluminium and silicon which are found in increased levels in plasma and tissues of uremic man. SOD activity was investigated in the erythrocytes of normal controls and of dialysis patients to determine if lack of SOD-protective activity could be a contributory cause to the increased hemolysis of uremia. It was found that SOD levels in red cell hemolysate were significantly lower in dialysis patients (41.4 ± 9.1 units/100 ml) compared to control (49.3 ± 7.2 units/100 ml) (U = 7.3; p < 0.005). When expressed per 100 ml of whole blood SOD levels were 3.25 ± 0.93 units/100 ml in dialysis patients and 6.46 ± 0.99 units/100 ml in controls (U = 96; p < 0.001). It is concluded that inhibition of SOD activity in the erythrocytes of dialysis patients may contribute to their anemia.

This article was published in Nephron and referenced in Journal of Clinical Research & Bioethics

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords