alexa Reduced venous compliance in lower limbs of aging humans and its importance for capacitance function.

Author(s): Olsen H, Lnne T

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Abstract Venous compliance in the calf of humans and its importance for capacitance function in relation to age were studied with the aid of 22, 44, and 59 mmHg lower body negative pressure (LBNP). Negative pressure transmission to the calf as well as changes in calf volume were studied, and venous compliance was calculated [change in volume with pressure change (dV/dP)]. The change in capacitance response of the calf with age (20-70 yr) was evaluated during LBNP 44 mmHg. Transmission of negative pressure to the subcutaneous tissue was almost full without any changes with age (92\%). However, it was reduced to 80\% in the underlying muscle tissue, irrespective of depth. Venous compliance in the young was 0.051 ml . 100 ml-1 . mmHg-1 and was reduced by 45\% to 0.029 ml . 100 ml-1 . mmHg-1 in the old (P < 0.05). Accordingly, the capacitance response was reduced by 0.015 ml . 100 ml-1 . yr-1 (P < 0.005). Furthermore, the hemodynamic response to hypovolemic circulatory stress was attenuated with age. The reduced pressure transmission in muscle tissue is probably due to restriction of the muscle fascia envelope. The reduced venous compliance with age and the concomitant reduction in capacitance response during LBNP have implications for both the sympathetic reflex responses as well as the capacitance response during acute hypovolemic circulatory stress, which might be defected in aging humans.
This article was published in Am J Physiol and referenced in

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