alexa Reduced viral burden amongst high responder patients following HIV-1 p24 peptide-based therapeutic immunization.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Proteomics & Bioinformatics

Author(s): Kran AM, Sommerfelt MA, Srensen B, Nyhus J, Baksaas I,

Abstract Share this page

Abstract We have previously shown that HIV p24-like peptides (Vacc-4x) via activation of skin dendritic cells induced immune responses in 90\% of HIV patients on highly active antiretroviral treatment (HAART). These patients (n=38) were here subjected to a final 14-week interruption of HAART. Patients with the highest delayed type hypersensitivity (DTH) responses to Vacc-4x-peptides before treatment interruption tended to achieve lower actual HIV RNA levels at the end of the study compared to Vacc-4x DTH low-responders (p=0.08) and significantly so in terms of viral loads relative to their individual pre-HAART HIV RNA set-points (p=0.04). CD4+ lymphocyte counts were maintained only among DTH high responders but decreased in the other patients during recurrent viremia (p
  • DOI: 10.1016/j.vaccine.2005.03.010
  • This article was published in Vaccine and referenced in Journal of Proteomics & Bioinformatics

    Relevant Expert PPTs

    Relevant Speaker PPTs

    Recommended Conferences

    • 9th International Conference on Bioinformatics
      October 23-24, 2017 Paris, France
    • 9th International Conference and Expo on Proteomics
      October 23-25, 2017 Paris, France

    Relevant Topics

    Peer Reviewed Journals
    Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
    International Conferences 2017-18
    Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

    Contact Us

    © 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version