alexa Reduction of LDL cholesterol by 25\% to 60\% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor.
Biomedical Sciences

Biomedical Sciences

Biology and Medicine

Author(s): Nawrocki JW, Weiss SR, Davidson MH, Sprecher DL, Schwartz SL,

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Abstract This 6-week, double-blind clinical trial evaluated lipid parameter responses to different dosages of atorvastatin in patients with primary hypercholesterolemia. Atorvastatin is a new 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor under development. After completing an 8-week placebo-baseline dietary phase, 81 patients were randomly assigned to receive either placebo or 2.5, 5, 10, 20, 40, or 80 mg atorvastatin once daily for 6 weeks. Plasma LDL cholesterol reductions from baseline were dose related, with 25\% to 61\% reduction from the minimum dose to the maximum dose of 80 mg atorvastatin once a day. Plasma total cholesterol and apo B reductions were also dose related. Previously, reductions in LDL cholesterol of the magnitude observed in this study have been seen only with combination drug therapy. In this study, atorvastatin was well tolerated by hyperlipidemic patients, had an acceptable safety profile, and provided greater reduction in cholesterol than other previously reported HMG-CoA reductase inhibitors.
This article was published in Arterioscler Thromb Vasc Biol and referenced in Biology and Medicine

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