Author(s): Dailey T, Tajiri N, Kaneko Y, Borlongan CV
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Abstract Stem cells possess a definitive role in neuronal rejuvenation following a cerebral injury. Whether endogenous, from the neurogenic niches of the subventricular zone and subgranular zone, or recruited from the bone marrow through peripheral circulation, accumulating evidence demonstrates that stem cells ameliorate the consequences of cerebrovascular events, particularly cerebral ischemia. In this chapter, we review milestone studies implicating the role of stem cells in response to disease. Furthermore, we outline specific mechanisms of action along with their clinical potential as therapeutic treatments for ischemic stroke. Copyright © 2013 S. Karger AG, Basel.
This article was published in Front Neurol Neurosci
and referenced in Journal of Stem Cell Research & Therapy