Author(s): Brandtzaeg P, Farstad IN, Haraldsen G
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Abstract According to the current paradigm of lymphocyte trafficking, primed B and T cells extravasate in the intestinal lamina propria chiefly by means of the mucosal homing receptor alpha4beta7, which interacts with the vascular addressin MAdCAM-1. However, as discussed here, this mechanism cannot explain the preferential homing of B cells with a high level of J-chain expression to mucosal effector sites outside the gut.
This article was published in Immunol Today
and referenced in Journal of Vaccines & Vaccination