alexa Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus.
Genetics & Molecular Biology

Genetics & Molecular Biology

Fungal Genomics & Biology

Author(s): Fortwendel JR, Juvvadi PR, Rogg LE, Steinbach WJ

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Abstract Here we show that expression of a constitutively activated RasA allele, as the sole source of Ras activity, revealed novel Ras-induced phenotypes, including excessive vacuolar expansion and spontaneous lysis of hyphal compartments. These findings highlight the requirement for balanced Ras activity in the establishment and maintenance of polarized growth in filamentous fungi.
This article was published in Eukaryot Cell and referenced in Fungal Genomics & Biology

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