Author(s): Orrenius S, Zhivotovsky B, Nicotera P, Orrenius S, Zhivotovsky B, Nicotera P
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Abstract To live or to die? This crucial question eloquently reflects the dual role of Ca2+ in living organisms--survival factor or ruthless killer. It has long been known that Ca2+ signals govern a host of vital cell functions and so are necessary for cell survival. However, more recently it has become clear that cellular Ca2+ overload, or perturbation of intracellular Ca2+ compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell death.
This article was published in Nat Rev Mol Cell Biol
and referenced in Journal of Cancer Science & Therapy