alexa Regulation of g protein-coupled receptor signaling by a-kinase anchoring proteins.


Journal of Physical Chemistry & Biophysics

Author(s): AppertCollin A, Baisamy L, Diviani D, AppertCollin A, Baisamy L, Diviani D, AppertCollin A, Baisamy L, Diviani D

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Abstract Specificity of transduction events is controlled at the molecular level by scaffold, anchoring, and adaptor proteins, which position signaling enzymes at proper subcellular localization. This allows their efficient catalytic activation and accurate substrate selection. A-kinase anchoring proteins (AKAPs) are group of functionally related proteins that compartmentalize the cAMP-dependent protein kinase (PKA) and other signaling enyzmes at precise subcellular sites in close proximity to their physiological substrate(s) and favor specific phosphorylation events. Recent evidence suggests that AKAP transduction complexes play a key role in regulating G protein-coupled receptor (GPCR) signaling. Regulation can occur at multiple levels because AKAPs have been shown both to directly modulate GPCR function and to act as downstream effectors of GPCR signaling. In this minireview, we focus on the molecular mechanisms through which AKAP-signaling complexes modulate GPCR transduction cascades. This article was published in J Recept Signal Transduct Res and referenced in Journal of Physical Chemistry & Biophysics

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