Author(s): Savitsky D, Tamura T, Yanai H, Taniguchi T
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Abstract Nine interferon regulatory factors (IRFs) compose a family of transcription factors in mammals. Although this family was originally identified in the context of the type I interferon system, subsequent studies have revealed much broader functions performed by IRF members in host defense. In this review, we provide an update on the current knowledge of their roles in immune responses, immune cell development, and regulation of oncogenesis.
This article was published in Cancer Immunol Immunother
and referenced in Journal of Genetic Syndromes & Gene Therapy