alexa Regulation of the genes of the bithorax complex in Drosophila
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Stem Cell Research & Therapy

Author(s): Lewis EB

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The BX-C is a set of master control genes that trans-regulate other genes and thereby control much of the segmentation pattern of the fly. The BX-C genes are themselves regulated in cis and trans. Three rules governing cis-regulation of BX-C are applicable over a region extending from Ubx to at least iab-7, a distance of nearly 300 kb on the DNA map: The colinearity (COL) rule: genes are colinear with respect to map location and order of expression along the body axis, the only exception thus far being pbx+; the cis-inactivation (CIN) rule: a mutant lesion in one gene tends to cis-inactivate the wild-type gene(s) immediately distally; and the cis-overexpression (COE) rule: certain mutant lesions in a given gene cause the next most proximal gene to overexpress one segment more anterior to the one in which the latter gene normally expresses. A model is proposed that attempts to account for these rules by invoking a special cis-regulatory entity (E) that diffuses more efficiently along the chromosome than between chromosomes.

This article was published in Cold Spring Harb Symp Quant Biol. and referenced in Journal of Stem Cell Research & Therapy

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