Author(s): Goldstein JL, Brown MS, Goldstein JL, Brown MS, Goldstein JL, Brown MS, Goldstein JL, Brown MS
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Abstract The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.
This article was published in Nature
and referenced in Rice Research: Open Access