Author(s): Sonenberg N, Hinnebusch AG
Abstract Share this page
Abstract Translational control in eukaryotic cells is critical for gene regulation during nutrient deprivation and stress, development and differentiation, nervous system function, aging, and disease. We describe recent advances in our understanding of the molecular structures and biochemical functions of the translation initiation machinery and summarize key strategies that mediate general or gene-specific translational control, particularly in mammalian systems.
This article was published in Cell
and referenced in Biochemistry & Analytical Biochemistry