alexa Regulatory mechanisms affecting the blast stem cells of acute myeloblastic leukemia.
Oncology

Oncology

Journal of Leukemia

Author(s): McCulloch EA

Abstract Share this page

Abstract Recent studies have indicated the existence of a novel regulatory system governing cell growth and differentiation. The system is based on the cellular homologues of the transforming genes (oncogenes) of retroviruses. Cellular oncogene products include regulators of the cell generation cycle, cell-surface receptors, and growth factors. Preliminary evidence is available that this regulatory system is important in hemopoiesis. In this paper, the biology of the blast cells of acute myeloblastic leukemia is reviewed. Data is presented indicating that genetic control may be exercised in the nucleus to affect self-renewal, at the cell surface, to mediate cell-to-cell interactions and through the environment by the production of growth factors. These findings support the suggestion that the blast population is a suitable model for studying oncogene-based regulation. Blasts have the further advantage that laboratory observations made with their use can be correlated with the clinical course of the disease.
This article was published in J Cell Physiol Suppl and referenced in Journal of Leukemia

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords