alexa Regulatory T cells and immune tolerance.
Cardiology

Cardiology

Journal of Clinical & Experimental Cardiology

Author(s): Sakaguchi S, Yamaguchi T, Nomura T, Ono M

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Abstract Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery. Recent research reveals the cellular and molecular basis of Treg development and function and implicates dysregulation of Tregs in immunological disease. This article was published in Cell and referenced in Journal of Clinical & Experimental Cardiology

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