alexa Regulatory T cells mediate maternal tolerance to the fetus.
Molecular Biology

Molecular Biology

Journal of Cell Science & Therapy

Author(s): Aluvihare VR, Kallikourdis M, Betz AG

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Abstract Pregnancy constitutes a major challenge to the maternal immune system, as it has to tolerate the persistence of paternal alloantigen. Although localized mechanisms contribute to fetal evasion from immune attack, maternal alloreactive lymphocytes persist. We demonstrate here an alloantigen-independent, systemic expansion of the maternal CD25+ T cell pool during pregnancy and show that this population contains dominant regulatory T cell activity. In addition to their function in suppressing autoimmune responses, maternal regulatory T cells suppressed an aggressive allogeneic response directed against the fetus. Their absence led to a failure of gestation due to immunological rejection of the fetus. This article was published in Nat Immunol and referenced in Journal of Cell Science & Therapy

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