Author(s): Mallat Z, AitOufella H, Tedgui A
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Abstract Atherosclerosis is an inflammatory disease of the arterial wall where both innate and adaptive T-cell-driven immunoinflammatory responses contribute to disease development. Recent studies from several groups suggest that subtypes of T cells, called regulatory T cells, previously shown to maintain immunologic tolerance, control the development and progression of atherosclerosis. Here, we summarize the current knowledge on the regulatory T-cell response in the context of atherosclerosis and the accumulating evidence for its central role in counteracting disease initiation and progression.
This article was published in Trends Cardiovasc Med
and referenced in Journal of Metabolic Syndrome