alexa Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Chiamulera C, EppingJordan MP, Zocchi A, Marcon C, Cottiny C,

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Abstract Both ionotropic and metabotropic glutamate receptors (mGluRs) are involved in the behavioral effects of pyschostimulants; however, the specific contributions of individual mGluR subtypes remain unknown. Here we show that mice lacking the mGluR5 gene do not self-administer cocaine, and show no increased locomotor activity following cocaine treatment, despite showing cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA) levels similar to wild-type (WT) mice. These results demonstrate a significant contribution of mGlu5 receptors to the behavioral effects of cocaine, and suggest that they may be involved in cocaine addiction. This article was published in Nat Neurosci and referenced in Journal of Addiction Research & Therapy

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