alexa Reiterated WG GW motifs form functionally and evolutionarily conserved ARGONAUTE-binding platforms in RNAi-related components.
Oncology

Oncology

Cancer Surgery

Author(s): ElShami M, Pontier D, Lahmy S, Braun L, Picart C, , ElShami M, Pontier D, Lahmy S, Braun L, Picart C,

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Abstract Two forms of RNA Polymerase IV (PolIVa/PolIVb) have been implicated in RNA-directed DNA methylation (RdDM) in Arabidopsis. Prevailing models imply a distinct function for PolIVb by association of Argonaute4 (AGO4) with the C-terminal domain (CTD) of its largest subunit NRPD1b. Here we show that the extended CTD of NRPD1b-type proteins exhibits conserved Argonaute-binding capacity through a WG/GW-rich region that functionally distinguishes Pol IVb from Pol IVa, and that is essential for RdDM. Site-specific mutagenesis and domain-swapping experiments between AtNRPD1b and the human protein GW182 demonstrated that reiterated WG/GW motifs form evolutionarily and functionally conserved Argonaute-binding platforms in RNA interference (RNAi)-related components.
This article was published in Genes Dev and referenced in Cancer Surgery

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